A global heart failure curriculum centered on guidelines, evidence-based medicine & real-world data to improve patient outcomes in the management of heart failure

Resources

2023 Focused Update of the 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure

McDonagh TA, Metra M, Adamo M, et al; ESC Scientific Document Group. 2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. Published online August 25, 2023. doi:10.1093/eurheartj/ehad195
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National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Guidelines for the Prevention, Detection, and Management of Heart Failure in Australia 2018

NHFA CSANZ Heart Failure Guidelines Working Group, Atherton JJ, Sindone A, et al. Heart Lung Circ. 2018;27(10):1123-1208.
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Expert Consensus Document on the Management of Hyperkalaemia in Patients with Cardiovascular Disease Treated with Renin Angiotensin Aldosterone System Inhibitors: Coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology

Rosano GMC, Tamargo J, Kjeldsen KP, et al. Eur Heart J Cardiovasc Pharmacother. 2018;4(3):180-188.
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2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America

Yancy CW, Jessup M, Bozkurt B, et al. J Am Coll Cardiol. 2017;70(6):776-803.
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2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-3726. doi:10.1093/eurheartj/ehab368

KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease

Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3S):S1-S87. doi:10.1016/j.kint.2020.11.003

Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology

Rosano GMC, Moura B, Metra M, et al. Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2021;23(6):872-881. doi:10.1002/ejhf.2206

GUIDELINE 11: Use of Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers in CKD

K/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease

Global burden of heart failure: a comprehensive and updated review of epidemiology

Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res. 2023;118(17):3272-3287. doi:10.1093/cvr/cvac013
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The ‘Ten Commandments’ of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Masini G, Graham FJ, Pellicori P, et al. Criteria for Iron Deficiency in Patients With Heart Failure. J Am Coll Cardiol. 2022;79(4):341-351. doi:10.1016/j.jacc.2021.11.039
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Estimating Lifetime Benefits of Comprehensive Disease-Modifying Pharmacological Therapies in Patients with Heart Failure with Reduced Ejection Fraction: A Comparative Analysis of Three Randomised Controlled Trials

Vaduganathan M, Claggett BL, Jhund PS, et al. Lancet. 2020; 396(10244):121-128.

New! Contemporary Drug Treatment of Chronic Heart Failure With Reduced Ejection Fraction: The CHECK-HF Registry

Brunner-La Rocca HP, Linssen GC, et al. JACC Heart Fail. 2019;7(1):13-21.

Factors Associated with Underuse of Mineralocorticoid Receptor Antagonists in Heart Failure with Reduced Ejection Fraction: An Analysis of 11 215 Patients from the Swedish Heart Failure Registry

Savarese G, Carrero JJ, Pitt B, et al. Eur J Heart Fail. 2018;20(9):1326-1334.
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Medical Therapy for Heart Failure with Reduced Ejection Fraction: The CHAMP-HF Registry

Greene SJ, Butler J, Albert NM et al. J Am Coll Cardiol. 2018;72(4):351-366.

Mineralocorticoid Receptor Antagonist Pattern of Use in Heart Failure with Reduced Ejection Fraction: Findings from BIOSTAT-CHF

Ferreira JP, Rossignol P, Machu JL, et al. Eur J Heart Fail. 2017;19(10):1284-1293.
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Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial

Butler J, Anker SD, Lund LH, et al. Eur Heart J. 2022;ehac401. doi:10.1093/eurheartj/ehac401
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Unravelling the Interplay Between Hyperkalaemia, Renin-angiotensin-aldosterone Inhibitor Use and Clinical Outcomes: Data from 9222 Chronic Heart Failure Patients of the ESC-HFA-EORP Heart Failure Long-Term Registry

Rossignol P, Lainscak M, Crespo-Leiro MG, et al. Eur J Heart Fail. Published online April 3, 2020. doi:10.1002/ejhf.1793

Association Between Potassium Level and Outcomes in Heart Failure with Reduced Ejection Fraction: A Cohort Study from the Swedish Heart Failure Registry

Cooper LB, Benson L, Mentz RJ, et al. Eur J Heart Fail. Published online February 20, 2020. doi:10.1002/ejhf.1757

Cardiovascular Risk Associated with Serum Potassium in the Context of Mineralocorticoid Receptor Antagonist Use in Patients with Heart Failure and Left Ventricular Dysfunction

Rossignol P, Duarte K, Girerd N, et al. Eur J Heart Fail. Published online January 9, 2020. doi:10.1002/ejhf.1724

Management of Hyperkalaemia in Acute Kidney Injury in a Heart Failure Patient with Patiromer

Slawik J, Dederer J, Kindermann I, Böhm M. ESC Heart Fail. 2020;7(5):3161–3164.
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Abnormalities of Potassium in Heart Failure: JACC State-of-the-Art Review

Ferreira JP, Butler J, Rossignol P, et al. J Am Coll Cardiol. 2020;75(22):2836-2850.

Daily Home Monitoring of Potassium, Creatinine, and Estimated Plasma Volume in Heart Failure Post-discharge.

Rossignol P, Fay R, Girerd N, Zannad F. ESC Heart Fail. 2020;7(3):1257-1263.
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Patiromer Sorbitex Calcium for Hyperkalaemia

Aust Prescr. 2020;43(1):28-29.
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Recurrent Hyperkalaemia Management and Use of Renin–angiotensin–aldosterone System Inhibitors: A European Multi-national Targeted Chart Review

Rossignol P, Ruilope LM, Cupisti A, et al. Clin Kidney J. 2019; 13(4):714-719.
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Efficacy and Safety of Sodium Zirconium Cyclosilicate for Treatment of Hyperkalemia: An 11-Month Open-Label Extension of HARMONIZE

Roger SD, Spinowitz BS, Lerma EV, et al. Am J Nephrol. 2019;50(6):473-480.
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Patiromer Versus Placebo to Enable Spironolactone Use in Patients with Resistant Hypertension and Chronic Kidney Disease (AMBER): A Phase 2, Randomised, Double-Blind, Placebo-Controlled Trial

Agarwal R, Rossignol P, Romero A, et al. Lancet. 2019;394(10208):1540-1550.
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Sodium Zirconium Cyclosilicate Among Individuals with Hyperkalemia: A 12-month Phase 3 Study

Spinowitz BS, Fishbane S, Pergola PE, et al. Clin J Am Soc Nephrol. 2019;14(6):798-809.
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Effect of Patiromer on Hyperkalemia Recurrence in Older Chronic Kidney Disease Patients Taking RAAS Inhibitors

Weir MR, Bushinsky DA, Benton WW, et al. Am J Med. 2018;131(5):555-564.e3.
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Long-Term Effects of Patiromer for Hyperkalaemia Treatment in Patients with Mild Heart Failure and Diabetic Nephropathy on Angiotensin-Converting Enzymes/Angiotensin Receptor Blockers: Results from AMETHYST-DN

Pitt B, Bakris GL, Weir MR, et al. ESC Heart Fail. 2018;5(4):592-602.
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Incidence, Predictors and CLINICAL MANAGEMENT of Hyperkalaemia in New Users of Mineralocorticoid Receptor Antagonists

Trevisan M, de Deco P, Xu H, et al. Eur J Heart Fail. 2018;20(8):1217-1226.
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Potassium and the Use of Renin-Angiotensin-Aldosterone System Inhibitors in Heart Failure with Reduced Ejection Fraction: Data From BIOSTAT-CHF

Beusekamp JC, Tromp J, van der Wal HH, et al. Eur J Heart Fail. 2018;20(5):923-930.
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Hyperkalemia After Initiating Renin-Angiotensin System Blockade: The Stockholm Creatinine Measurements (SCREAM) Project

Bandak G, Sang Y, Gasparini A, et al. J Am Heart Assoc. 2017;6(7):e005428.
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Hyperkalemia: pharmacotherapies and clinical considerations

Sinnathamby ES, Banh KT, Barham WT, et al. Hyperkalemia: pharmacotherapies and clinical considerations. Cureus. 2024;16(1):e52994. doi:10.7759/cureus.52994

Consensus statement on the management of hyperkalaemia–an Asia-Pacific perspective

Yap DYH, Ma RCW, Wong ECK, et al. Consensus statement on the management of hyperkalaemia–an Asia-Pacific perspective. Nephrology (Carlton). Published online February 25, 2024. doi:10.1111/nep.14281
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Long-term patiromer use and outcomes among US veterans with hyperkalemia and CKD: a propensity-matched cohort study

Obi Y, Thomas F, Dashputre AA, Goedecke P, Kovesdy CP. Long-term patiromer use and outcomes among US veterans with hyperkalemia and CKD: a propensity-matched cohort study. Kidney Med. 2023;6(1):100757. doi:10.1016/j.xkme.2023.100757

The Efficacy and Safety of New Potassium Binders on Renin-Angiotensin-Aldosterone System Inhibitor Optimization in Heart Failure Patients: A Systematic Review and Meta-Analysis

Abuelazm M, Badr A, Turkmani M, et al. The efficacy and safety of new potassium binders on renin-angiotensin-aldosterone system inhibitor optimization in heart failure patients: a systematic review and meta-analysis. ESC Heart Fail. Published online November 27, 2023. doi:10.1002/ehf2.14588
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Evaluation of Longer- vs Short-Term Use of Patiromer on Health Care Resource Utilization in the Patiromer Longer-Term Use Evaluation (VALUE) Study

Gupta A, Kammerer J, Shaik I, Mukherjee KG, Oliveira J, Thakar C. Evaluation of longer- vs short-term use of patiromer on health care resource utilization in the patiromer longer-term use evaluation (VALUE) study. J Manag Care Spec Pharm. Published online November 15, 2023. doi:10.18553/jmcp.2023.23100
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Recommendations for the Management of Hyperkalemia in Patients Receiving Renin-Angiotensin-Aldosterone System Inhibitors

De Nicola L, Ferraro PM, Montagnani A, Pontremoli R, Dentali F, Sesti G. Recommendations for the management of hyperkalemia in patients receiving renin-angiotensin-aldosterone system inhibitors. Intern Emerg Med. Published online September 29, 2023. doi:10.1007/s11739-023-03427-0
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The Efficacy and Safety of Patiromer for Heart Failure Patients: A Systematic Review and Meta‑Analysis

Wang Y, Gao Y, Feng J, Hou L, Luo C, Zhang Z. The efficacy and safety of patiromer for heart failure patients: a systematic review and meta-analysis. Cardiovasc Drugs Ther. Published online June 7, 2023. doi:10.1007/s10557-023-07473-w.
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Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebocontrolled, parallel-group study

Rafique Z, Budden J, Quinn CM, et al. Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebo-controlled, parallel-group study. BMJ Open. 2023;13(6):e071311. doi:10.1136/bmjopen-2022-071311
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Potassium Homeostasis and Management of Dyskalemia in Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Clase CM, Carrero JJ, Ellison DH, et al. Kidney Int. 2020;97(1):42-61.
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Management of Hyperkalaemia in Acute Kidney Injury in a Heart Failure Patient with Patiromer

Slawik J, Dederer J, Kindermann I, Böhm M. ESC Heart Fail. 2020;7(5):3161–3164.
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A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study of Sodium Zirconium Cyclosilicate for Reducing the Incidence of Predialysis Hyperkalemia

Fishbane S, Ford M, Fukagawa M, et al. J Am Soc Nephrol. 2019;30(9):1723-1733.
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Sodium Zirconium Cyclosilicate Among Individuals with Hyperkalemia: A 12-month Phase 3 Study

Spinowitz BS, Fishbane S, Pergola PE, et al. Clin J Am Soc Nephrol. 2019;14(6):798-809.
PDF Download

Long-Term Effects of Patiromer for Hyperkalaemia Treatment in Patients with Mild Heart Failure and Diabetic Nephropathy on Angiotensin-Converting Enzymes/Angiotensin Receptor Blockers: Results from AMETHYST-DN

Pitt B, Bakris GL, Weir MR, et al. ESC Heart Fail. 2018;5(4):592-602.
PDF Download

Incidence, Predictors and CLINICAL MANAGEMENT of Hyperkalaemia in New Users of Mineralocorticoid Receptor Antagonists

Trevisan M, de Deco P, Xu H, et al. Eur J Heart Fail. 2018;20(8):1217-1226.
PDF Download

Hyperkalemia After Initiating Renin-Angiotensin System Blockade: The Stockholm Creatinine Measurements (SCREAM) Project

Bandak G, Sang Y, Gasparini A, et al. J Am Heart Assoc. 2017;6(7):e005428.
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Improving the outcome of patients with heart failure: assessment of iron deficiency and intravenous iron replacement

Yera HO, Khan A, Akinlade OM, Champsi A, Glouzon VNJ, Spencer C. Improving the outcome of patients with heart failure: assessment of iron deficiency and intravenous iron replacement. Cureus. 2023;15(10):e47027. doi:10.7759/cureus.47027

Hierarchical end points in prior heart failure trials and the HEART-FID trial

Harrington J, Mentz RJ, Rockhold FW, et al. Hierarchical end points in prior heart failure trials and the HEART-FID trial. Circ Heart Fail. 2024;17(2):e010676. doi:10.1161/CIRCHEARTFAILURE.123.010676

Increasing rates of screening and treatment of iron deficiency in ambulatory patients with heart failure with reduced ejection fraction: a quality improvement cohort study

Gewarges M, Mainland R, Wilkinson K, et al. Increasing rates of screening and treatment of iron deficiency in ambulatory patients with heart failure with reduced ejection fraction: a quality improvement cohort study. BMJ Open Qual. 2024;13(1):e002584. doi:10.1136/bmjoq-2023-002584

Iron deficiency in heart failure with reduced ejection fraction: improving treatment on the cardiology ward

Al-Hadithi A, Hurley P, Cacciottolo P. Iron deficiency in heart failure with reduced ejection fraction: improving treatment on the cardiology ward. Clin Med (Lond). 2023;23(Suppl 6):99. doi:10.7861/clinmed.23-6-s99
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Early improvement of global longitudinal strain after iron deficiency correction in heart failure with reduced ejection fraction

Sutil-Vega M, Rizzo M, Colomer-Asenjo Í, et al. Early improvement of global longitudinal strain after iron deficiency correction in heart failure with reduced ejection fraction. Echocardiography. 2024;41(1):e15726. doi:10.1111/echo.15726

Improving the Outcome of Patients With Heart Failure: Assessment of Iron Deficiency and Intravenous Iron Replacement

Yera HO, Khan A, Akinlade OM, Champsi A, Glouzon VNJ, Spencer C. Improving the outcome of patients with heart failure: assessment of iron deficiency and intravenous iron replacement. Cureus. 2023;15(10):e47027. doi:10.7759/cureus.47027

Iron Deficiency in Heart Failure: A Korea-Oriented Review

Jankowska EA, Ponikowski P. Iron deficiency in heart failure: a Korea-oriented review. Int J Heart Fail. 2023;5(4):173-183. doi:10.36628/ijhf.2023.0032
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Intravenous Iron Supplementation Improves Energy Metabolism of Exercising Skeletal Muscles Without Effect on Either Oxidative Stress or Inflammation in Male Patients With Heart Failure With Reduced Ejection Fraction

Drozd MD, Tkaczyszyn M, Kasztura M, et al. Intravenous iron supplementation improves energy metabolism of exercising skeletal muscles without effect on either oxidative stress or inflammation in male patients with heart failure with reduced ejection fraction. Cardiol J. Published online October 19, 2023. doi:10.5603/cj.97253
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Ferric Carboxymaltose in Heart Failure with Iron Deficiency

Mentz RJ, Garg J, Rockhold FW, et al; HEART-FID Investigators. Ferric Carboxymaltose in heart failure with iron deficiency. N Engl J Med. Published online August 26, 2023. doi:10.1056/NEJMoa2304968

Treating Iron Deficiency in Heart Failure

Martens P, Mullens W. Treating iron deficiency in heart failure. N Engl J Med. Published online August 26, 2023. doi:10.1056/NEJMe2308305

Efficacy of Ferric Carboxymaltose in Heart Failure with Iron Deficiency: An Individual Patient Data Meta-Analysis

Ponikowski P, Mentz RJ, Hernandez AF, et al. Efficacy of ferric carboxymaltose in heart failure with iron deficiency: an individual patient data meta-analysis. Eur Heart J. Published online August 26, 2023. doi:10.1093/eurheartj/ehad586
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Effect of intravenous iron replacement on recurrent heart failure hospitalizations and cardiovascular mortality in patients with heart failure and iron deficiency: A Bayesian meta-analysis

Anker SD, Khan MS, Butler J, et al. Effect of intravenous iron replacement on recurrent heart failure hospitalizations and cardiovascular mortality in patients with heart failure and iron deficiency: a Bayesian meta-analysis. Eur J Heart Fail. Published online April 16, 2023. doi:10.1002/ejhf.2860
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Intravenous iron in patients with heart failure and iron deficiency: an updated meta-analysis

Graham FJ, Pellicori P, Kalra PR, Ford I, Bruzzese D, Cleland JGF. Intravenous iron in patients with heart failure and iron deficiency: an updated meta-analysis. Eur J Heart Fail. 2023;25(4):528-537. doi:10.1002/ejhf.2810
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Ferric Carboxymaltose in Iron-Deficient Patients with Hospitalized Heart Failure and Reduced Kidney Function

Macdougall IC, Ponikowski P, Stack AG, et al. Ferric carboxymaltose in iron-deficient patients with hospitalized heart failure and reduced kidney function. Clin J Am Soc Nephrol. Published online June 29, 2023. doi:10.2215/CJN.0000000000000223.

Association Between Hemoglobin Levels and Efficacy of Intravenous Ferric Carboxymaltose in Patients With Acute Heart Failure and Iron Deficiency: An AFFIRM-AHF Subgroup Analysis

Filippatos G, Ponikowski P, Farmakis D, et al; AFFIRM-AHF Investigators. Association between hemoglobin levels and efficacy of intravenous ferric carboxymaltose in patients with acute heart failure and iron deficiency: an AFFIRM-AHF subgroup analysis. Circulation. 2023;147(22):1640-1653. doi:10.1161/CIRCULATIONAHA.122.060757
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Iron Deficiency in Heart Failure: A Scientific Statement from the Heart Failure Society of America

Beavers CJ, Ambrosy AP, Butler J, et al. Iron deficiency in heart failure: a scientific statement from the Heart Failure Society of America. J Card Fail. Published online May 1, 2023. doi:10.1016/j.cardfail.2023.03.025
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Impact of ischaemic aetiology on the efficacy of intravenous ferric carboxymaltose in patients with iron deficiency and acute heart failure: insights from the AFFIRM-AHF trial

Metra M, Jankowska EA, Pagnesi M, et al. Eur J Heart Fail. 2022;10.1002/ejhf.2630. doi:10.1002/ejhf.2630
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Criteria for Iron Deficiency in Patients with Heart Failure

Masini G, Graham FJ, Pellicori P, et al. Criteria for Iron Deficiency in Patients With Heart Failure. J Am Coll Cardiol. 2022;79(4):341-351. doi:10.1016/j.jacc.2021.11.039
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Practical Guidance for Diagnosing and Treating Iron Deficiency in Patients with Heart Failure: Why, Who and How?

Sindone A, Doehner W, Manito N, et al. Practical Guidance for Diagnosing and Treating Iron Deficiency in Patients with Heart Failure: Why, Who and How?. J Clin Med. 2022;11(11):2976. Published 2022 May 25. doi:10.3390/jcm11112976
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Ferric Carboxymaltose for Iron Deficiency at Discharge after Acute Heart Failure: A Multicentre, Double-Blind, Randomised, Controlled Trial

Ponikowski P, Kirwan B, Anker SD, et al. Lancet. 2020;396(10266):1895-1904. doi:10.1016/S0140-6736(20)32339-4

Iron Deficiency in 78 805 People Admitted with Heart Failure Across England: A Retrospective Cohort Study

Beattie JM, Khatib R, Phillips CJ, Williams SG. Open Heart. 2020;7(1):e001153.
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Iron Deficiency: Impact on Functional Capacity and Quality of Life in Heart Failure with Preserved Ejection Fraction

Alcaide-Aldeano A, Garay A, Alcoberro L, et al. J Clin Med. 2020;9(4):1199.
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Rationale and Design of the AFFIRM-AHF Trial: A Randomised, Double-Blind, Placebo-Controlled Trial Comparing the Effect of Intravenous Ferric Carboxymaltose on Hospitalisations and Mortality in Iron-Deficient Patients Admitted for Acute Heart Failure

Ponikowski P, Kirwan BA, Anker SD, et al. Eur J Heart Fail. 2019;21(12):1651-1658.
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Iron Deficiency in Heart Failure: An Overview

von Haehling S, Ebner N, Evertz R, Ponikowski P, Anker SD. JACC Heart Fail. 2019;7(1):36-46.

Effects of Ferric Carboxymaltose on Hospitalisations and Mortality Rates in Iron-Deficient Heart Failure Patients: An Individual Patient Data Meta-Analysis

Anker SD, Kirwan BA, van Veldhuisen DJ, et al. Eur J Heart Fail. 2018;20(1):125-133.
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Screening, Diagnosis and Treatment of Iron Deficiency in Chronic Heart Failure: Putting the 2016 European Society of Cardiology Heart Failure Guidelines into Clinical Practice

McDonagh T, Damy T, Doehner W, et al. Eur J Heart Fail. 2018;20(12):1664-1672.
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Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial

Lewis GD, Malhotra R, Hernandez AF, et al. JAMA. 2017;317(19):1958-1966.
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Effect of Ferric Carboxymaltose on Exercise Capacity in Patients with Chronic Heart Failure and Iron Deficiency

van Veldhuisen DJ, Ponikowski P, van der Meer P, et al. Circulation. 2017;136(15):1374-1383.
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Common Misconceptions About Iron Deficiency in Heart Failure and What to Do About It

Slides from a podcast discussing the prevalence of iron deficiency and the evidence supporting its screening and management in heart failure.

Iron Deficiency in Heart Failure

A comprehensive slide presentation with notes on the latest data examining the role of iron deficiency as a risk factor in heart failure. Evidence and recommendations for the use of intravenous iron to correct deficiencies and improve patient outcomes is presented.
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Iron Deficiency & Anemia

A quick reference guide to diagnosing and correcting iron deficiency.
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Abnormalities of Potassium in Heart Failure

Ferreira JP, Butler J, Rossignol P, et al. Abnormalities of Potassium in Heart Failure: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;75(22):2836-2850. doi:10.1016/j.jacc.2020.04.021

AHA 2020: New Insights on Iron Deficiency and Heart Failure

Slides from a panel discussion on new data from AFFIRM-AHF showing reductions in rehospitalization when correcting iron deficiency in patients stabilized after an episode of acute heart failure.
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Clinical Implications of Managing Iron Deficiency from AFFIRM-AHF

Slides from a panel discussion on changes to integrate into practice based on new data from AFFIRM-AHF.
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Don’t Be Fooled: It’s Iron Deficiency, Not Just Anemia

Slides from a podcast discussing when patients with heart failure should be screened and how to best treat those with iron deficiency.
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Effect of patiromer on serum potassium in hyperkalemic patients with heart failure: Pooled analysis of 3 randomized trials

Piña IL, Yuan J, Ackourey G, Ventura H. Effect of patiromer on serum potassium in hyperkalemic patients with heart failure: Pooled analysis of 3 randomized trials. Prog Cardiovasc Dis. 2020;63(5):656-661. doi:10.1016/j.pcad.2020.09.007

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-3726. doi:10.1093/eurheartj/ehab368

Ferric carboxymaltose for the treatment of iron deficiency in heart failure: a multinational cost-effectiveness analysis utilising AFFIRM-AHF

McEwan P, Ponikowski P, Davis JA, et al. Ferric carboxymaltose for the treatment of iron deficiency in heart failure: a multinational cost-effectiveness analysis utilising AFFIRM-AHF [published online ahead of print, 2021 Jun 30]. Eur J Heart Fail. 2021;10.1002/ejhf.2270. doi:10.1002/ejhf.2270

The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study

Jankowska EA, Kirwan BA, Kosiborod M, et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study [published online ahead of print, 2021 Jun 3]. Eur Heart J. 2021;42(31):3011-3020. doi:10.1093/eurheartj/ehab234

Hyperkalemia Management in Older Adults With Diabetic Kidney Disease Receiving Renin-Angiotensin-Aldosterone System Inhibitors: A Post Hoc Analysis of the AMETHYST-DN Clinical Trial

Bakris GL, Woods SD, Alvarez PJ, Arthur SP, Kumar R. Hyperkalemia Management in Older Adults With Diabetic Kidney Disease Receiving Renin-Angiotensin-Aldosterone System Inhibitors: A Post Hoc Analysis of the AMETHYST-DN Clinical Trial. Kidney Med. 2021;3(3):360-367.e1. Published 2021 Mar 13. doi:10.1016/j.xkme.2021.01.005

Iron Deficiency and Anemia: What’s the Difference?

A 3D mechanism of action animation examining the relationship between iron deficiency, anemia, and heart failure.

Iron Deficiency in Heart Failure

A comprehensive slide presentation with notes on the latest data examining the role of iron deficiency as a risk factor in heart failure. Evidence and recommendations for the use of intravenous iron to correct deficiencies and improve patient outcomes is presented.
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KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease

Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int. 2021;99(3S):S1-S87. doi:10.1016/j.kint.2020.11.003

Management of Heart Failure: Time to Consider New Options?

Slides from an expert interview examining the evidence around the long-term use of potassium binders to manage serum potassium levels and support treatment with guideline-directed RAASi therapy.
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Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology

Rosano GMC, Moura B, Metra M, et al. Patient profiling in heart failure for tailoring medical therapy. A consensus document of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2021;23(6):872-881. doi:10.1002/ejhf.2206

Patiromer to Enable Spironolactone in Patients with Resistant Hypertension and CKD (AMBER): Results in the Prespecified Subgroup with Diabetes

Agarwal R, Rossignol P, Mayo MR, et al. Patiromer to Enable Spironolactone in Patients with Resistant Hypertension and CKD (AMBER): Results in the Prespecified Subgroup with Diabetes. Clin J Am Soc Nephrol. 2021;16(9):1407-1409. doi:10.2215/CJN.02890221

Potassium Management

A clinical guide for potassium binder use and mineralocorticoid receptor antagonist dose adjustments in response to serum potassium values.
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Potassium Management in Patients at Risk for Hyperkalemia

A comprehensive slide presentation with notes on hyperkalemia as a risk marker for poor outcomes due to under-dosing of RAASi therapy. Evidence and recommendations surrounding new strategies for managing hyperkalemia in daily practice is presented.
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Safety and Tolerability of the Potassium Binder Patiromer From a Global Pharmacovigilance Database Collected Over 4 Years Compared with Data from the Clinical Trial Program

Rossignol P, David L, Chan C, Conrad A, Weir MR. Safety and Tolerability of the Potassium Binder Patiromer From a Global Pharmacovigilance Database Collected Over 4 Years Compared with Data from the Clinical Trial Program. Drugs Real World Outcomes. 2021;8(3):315-323. doi:10.1007/s40801-021-00254-7

Simultaneous or Rapid Sequence Initiation of Quadruple Medical Therapy for Heart Failure-Optimizing Therapy With the Need for Speed

Greene SJ, Butler J, Fonarow GC. Simultaneous or Rapid Sequence Initiation of Quadruple Medical Therapy for Heart Failure-Optimizing Therapy With the Need for Speed. JAMA Cardiol. 2021;6(7):743-744. doi:10.1001/jamacardio.2021.0496

6-Minute Walk Test

How to assess the functional capacity of patients with heart failure.
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AHA Heart Failure Tools and Resources for Patients

Downloadable and interactive resources for patients with heart failure including a self-management tool, symptom tracker, and questions to ask your doctor. Spanish language resources are available.

Heart Foundation of Australia Heart Failure Resources for Patients

Resources to help educate patients with heart failure which include a video series, toolkit, and booklet on how to live well with heart failure.

ESC Heartfailurematters.org Patient Education Website

Available in 10 languages, this website provides useful tools and videos for patients with heart failure and their caregivers.

Potassium and Heart Failure

An educational handout for patients on dietary considerations surrounding potassium and heart failure.
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